For the record I have used as many as six instances of Dune 3 in a project with no crashes but again I don't own Ableton Live. No Problems at all in FL Studio, Reaper, or Sonar.
I don't know if anyone else here uses Ableton but I'm pretty sure Synapse would have heard by now if multiple instances frequently caused Ableton Live to crash as it's a popular DAW.
Anyway if any of the regulars here use Ableton 10.1 can you give it a test with D3 please ?